John Isner falls to 2-6 in his FedEx ATP Head2Head series with Roger Federer, who is now a four-time Miami champion.

One year after lifting his first ATP Masters 1000 trophy in Miami, John Isner finishes runner-up to Roger Federer.

Defending champion John Isner defeats #NextGenATP Canadian Felix Auger-Aliassime to win his 11th consecutive match in Miami.

John Isner will try to reach his second Miami Open presented by Itau final this week.

John Isner won his maiden ATP Masters 1000 title last year in Miami.

Defending champion John Isner is into the Miami quarter-finals for the third time.

John Isner owns a 21-10 record at the Miami Open presented by Itau.

John Isner owns a 21-10 record at the Miami Open presented by Itau.

John Isner looks to go back-to-back at the Miami Open presented by Itau.

Alexander Zverev and John Isner helped out the Greater Humane Society of Miami as part of Miami Unites Day.

John Isner loses just two games on Sunday in his second-round win against #NextGenATP Aussie Alexei Popyrin.

John Isner completed his Acapulco quarter-final victory over John Millman shortly after 2:30 a.m. local time on Friday morning.

John Isner hits a forehand in his quarter-final victory over Adrian Mannarino at the Delray Beach Open.

John Isner poses during the ceremonial puck drop for the NHL game between the Florida Panthers and the Carolina Hurricanes.

John Isner strikes a backhand in his quarter-final against Adrian Mannarino at the Delray Beach Open by VITACOST.com

John Isner closes in on his fourth semi-final at the Delray Beach Open.

John Isner hits 33 aces on Wednesday en route to the New York Open quarter-finals.

John Isner ends his 2018 season with a 34-22 tour-level record after falling in straight sets to Alexander Zverev at the Nitto ATP Finals on Friday.

John Isner will meet Alexander Zverev in his final Group Guga Kuerten match at the Nitto ATP Finals on Friday.

John Isner has captured two tour-level trophies this season.

John Isner saves six of nine break points in straight-sets loss to Novak Djokovic at the Nitto ATP Finals on Monday.

At 6'10", John Isner is the tallest player to ever compete at the Nitto ATP Finals.

The eight singles players competing at the Nitto ATP Finals take the Jubilee line on the London Underground from North Greenwich station to Westminster station to attend the Nitto ATP Finals Official Launch presented by Moët & Chandon at London's iconic Houses of Parliament on November 9, 2018 in London, England. The tournament will be played 11-18 November at The O2.

The eight singles players competing at the Nitto ATP Finals take the Jubilee line on the London Underground from North Greenwich station to Westminster station to attend the Nitto ATP Finals Official Launch presented by Moët & Chandon at London's iconic Houses of Parliament on November 9, 2018 in London, England. The tournament will be played 11-18 November at The O2.

The elite eight have arrived in London for the Nitto ATP Finals.